DEPARTMENT OF CHEMISTRY
GEORGIA STATE UNIVERSITY

The Iyer Group

  1. Das A, Cui X, Chivukula V, Iyer SS. Detection of Enzymes, Viruses, and Bacteria Using Glucose Meters. Anal. Chem. 2018, 90, 11589-11598. DOI:10.1021/acs.analchem.8b02960

  2. Yang Y, He HJ, Chang H, Yu Y, Yang MB, He Y, Fan ZC, Iyer SS, Yu P. Multivalent oleanolic acid human serum albumin conjugate as nonglycosylated neomucin for influenza virus capture and entry inhibition. Eur. J. Med. Chem. 2018, 143, 1723-1731. DOI:10.1016/j.ejmech.2017.10.070

  3. Cui X, Das A, Dhawane AN, Sweeney J, Zhang X, Chivukula V, Iyer SS. Highly specific and rapid glycan based amperometric detection of influenza viruses. Chem. Sci. 2017, 8, 3628-3634. DOI:10.1039/C6SC03720H

  4. Gurale BP, He Y, Cui X, Dinh H, Dhawane AN, Lucchi NW, Udhayakumar V, Iyer SS. Toward the Development of the Next Generation of a Rapid Diagnostic Test: Synthesis of Glycophosphatidylinositol (GPI) Analogues of Plasmodium falciparum and Immunological Characterization. Bioconjugate Chem. 2016, 27, 2886-2899. DOI:10.1021/acs.bioconjchem.6b00542

  5. Yang Y, Liu HP, Yu Q, Yang MB, Wang DM, Jia TW, He HJ, He Y, Xiao HX, Iyer SS, Fan ZC, Meng X, Yu P. Multivalent S-sialoside protein conjugates block influenza hemagglutinin and neuraminidase. Carbohydr. Res. 2016, 435, 68-75. DOI:10.1016/j.carres.2016.09.017

  6. Dhawane AN, Diez-Valcarce M, Gurale BP, Dinh H, Vinjé J, Iyer SS. Synthesis and Evaluation of Biotinylated Bivalent HistoBlood Group Antigens for Capturing Human Noroviruses. Bioconjugate Chem. 2016, 27, 1822-1829. DOI:10.1021/acs.bioconjchem.6b00226

  7. Zhang WQ, He Y, Yu Q, Liu HP, Wang DM, Li XB, Luo J, Meng X, Qin HJ, Lucchi NW, Udhayakumar V, Iyer SS, Yang Y, Yu P. Polyvalent effect enhances diglycosidic antiplasmodial activity. Eur. J. Med. Chem. 2016, 121, 640-648. DOI:10.1016/j.ejmech.2016.05.069

  8. He Y, Yang Y, Iyer SS. Neuraminidase Resistant Sialosides for the Detection of Influenza Viruses. Bioconjugate Chem. 2016, 27, 1509-1517. DOI:10.1021/acs.bioconjchem.6b00150

  9. Gurale BP, Dhawane AN, Cui X, Das A, Zhang X, Iyer SS. Indirect Detection of Glycosidases Using Amperometry. Anal Chem. 2016, 88, 4248-4253. DOI:10.1021/acs.analchem.5b03943

  10. Zhang X, Dhawane AN, Sweeney J, He Y, Vasireddi M, Iyer SS. Electrochemical assay to detect influenza viruses and measure drug susceptibility. Angew. Chem. Int. Ed. 2015, 54, 5929-5932. DOI:10.1002/anie.201412164

  11. Dinh H, Zhang X, Sweeney J, Yang Y, He Y, Dhawane A, Iyer SS. Glycan based detection and drug susceptibility of influenza virus. Anal Chem. 2014, 86, 8238-8244. DOI:10.1021/ac501624v

  12. Yang Y, He Y, Li X, Dinh H, Iyer SS. Bifunctional thiosialosides inhibit influenza virus. Bioorg. Med. Chem. Lett. 2014, 24, 636-643. DOI:10.1016/j.bmcl.2013.11.077

  13. Yosief HO, Iyer SS, Weiss AA. Binding of Pk-trisaccharide analogs of globotriaosylceramide to Shiga toxin variants. Infect. Immun. 2013, 81, 2753-2760. DOI:10.1128/IAI.00274-13

  14. Yosief HO, Weiss AA, Iyer SS. Capture of uropathogenic E. coli by using synthetic glycan ligands specific for the pap-pilus. Chembiochem. 2013, 14, 251-259. DOI:10.1002/cbic.201200582

  15. Guo X, Kulkarni A, Doepke A, Halsall HB, Iyer S, Heineman WR. Carbohydrate-based label-free detection of Escherichia coli ORN 178 using electrochemical impedance spectroscopy. Anal Chem. 2012, 84, 241-246. DOI:10.1021/ac202419u

  16. Kulkarni AA, Weiss AA, Iyer SS. Detection of carbohydrate binding proteins using magnetic relaxation switches. Anal Chem. 2010, 82, 7430-7435. DOI:10.1021/ac101579m

  17. Kulkarni AA, Fuller C, Korman H, Weiss AA, Iyer SS. Glycan encapsulated gold nanoparticles selectively inhibit shiga toxins 1 and 2. Bioconjugate Chem. 2010, 21, 1486-1493. DOI:10.1021/bc100095w

  18. Millen SH, Lewallen DM, Herr AB, Iyer SS, Weiss AA. Identification and characterization of the carbohydrate ligands recognized by pertussis toxin via a glycan microarray and surface plasmon resonance. Biochemistry, 2010, 49, 5954-5967. DOI:10.1021/bi100474z

  19. Kulkarni AA, Weiss AA, Iyer SS. Glycan-based high-affinity ligands for toxins and pathogen receptors. Med. Res. Rev. 2010, 30, 327-393. DOI:10.1002/med.20196

  20. Flagler MJ, Mahajan SS, Kulkarni AA, Iyer SS, Weiss AA. Comparison of binding platforms yields insights into receptor binding differences between shiga toxins 1 and 2. Biochemistry. 2010, 49, 1649-1657. DOI:10.1021/bi902084y

  21. Lewallen DM, Siler D, Iyer SS. Factors affecting protein-glycan specificity: effect of spacers and incubation time. Chembiochem. 2009, 10, 1486-1489. DOI:10.1002/cbic.200900211

  22. Hatch DM, Weiss AA, Kale RR, Iyer SS. Biotinylated bi- and tetra-antennary glycoconjugates for Escherichia coli detection. Chembiochem. 2008, 9, 2433-2442. DOI:10.1002/cbic.200800188

  23. Kale RR, Mukundan H, Price DN, Harris JF, Lewallen DM, Swanson BI, Schmidt JG, Iyer SS. Detection of intact influenza viruses using biotinylated biantennary S-sialosides. J. Am. Chem. Soc. 2008, 130, 8169-8171. DOI:10.1021/ja800842v

  24. Kale RR, McGannon CM, Fuller-Schaefer C, Hatch DM, Flagler MJ, Gamage SD, Weiss AA, Iyer SS. Differentiation between structurally homologous Shiga 1 and Shiga 2 toxins by using synthetic glycoconjugates. Angew. Chem. Int. Ed. 2008, 47, 1265-1268. DOI:10.1002/anie.200703680

  25. Rele SM, Iyer SS, Chaikof EL. Hyaluronan-based Glycoclusters as Probes for Chemical Glycobiology. Tetrahedron Lett. 2007, 48, 5055-5060. DOI:10.1016/j.tetlet.2007.05.097

  26. Kale RR, Clancy CM, Vermillion RM, Johnson EA, Iyer SS. Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A. Bioorg. Med. Chem. Lett. 2007, 17, 2459-2464. DOI:10.1016/j.bmcl.2007.02.028

  27. Rele SM, Iyer SS, Baskaran S, Chaikof EL. Design and synthesis of dimeric heparinoid mimetics. J. Org. Chem. 2004, 69, 9159-9170. DOI:10.1021/jo049092r

  28. Iyer S, Rele S, Grasa G, Nolan S, Chaikof EL. Synthesis of a hyaluronan neoglycopolymer by ring-opening metathesis polymerization. Chem. Commun. (Camb). 2003, 1315, 18-19. DOI:10.1039/B301734F